So far switching from one major version to the next was always relatively easy and if you have comfort update it is even easier. However, also test the new version in a test installation before you upgrade your production server, checking if everything that you really need works fine, anything custom made (themes, workarounds, etc.) are still working, etc.
Then backup your database and everything, and only then proceed to upgrade your production environment.
But this should be basic standard anyway, for any production environment.
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The following user(s) said Thank You: cdorin, Indispirit